Article 1
Regulation (EC) No 1272/2008 is amended as follows: (1) Annex VI is amended in accordance with the Annex to this Regulation; (2) in Annex VI, Table 3.2 is deleted.
Commission Regulation (EU) 2016/1179 of 19 July 2016 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (Text with EEA relevance)
Commission Regulation (EU) 2016/1179 of 19 July 2016 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (Text with EEA relevance)
Data as of 2026-07-04 · Compiled from an official source version. Later amendments or repeals may not be reflected; the official text prevails. · Read the official text ↗
Article 2
1. This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union . 2. This Regulation shall apply from 1 March 2018. Article 1(2) shall apply from 1 June 2017. 3. By way of derogation from paragraph 2, substances and mixtures may, before 1 March 2018, be classified, labelled and packaged in accordance with Regulation (EC) No 1272/2008 as amended by this Regulation.
Supplementary provisions
ANNEXSupplementary provisions
ANNEX Table 3.1 of Part 3 of Annex VI to Regulation (EC) No 1272/2008 is amended as follows: (a) the entries corresponding to index numbers 607-331-00-5 and 609-066-00-0 are deleted; (b) the entries corresponding to index numbers, 006-035-00-8, 029-002-00-X, 602-020-00-0, 602-033-00-1, 603-055-00-4, 604-030-00-0, 604-092-00-9, 605-013-00-0, 605-022-00-X, 606-014-00-9, 606-021-00-7, 607-056-00-0, 607-059-00-7, 607-157-00-X, 607-172-00-1, 607-375-00-5, 607-623-00-2, 613-166-00-X, 613-121-00-4, 616-011-00-4, 616-037-00-6 and 616-207-00-X are replaced by the following entries respectively: Index No International Chemical Identification EC No CAS No Classification Labelling Specific Conc. Limits, M-factors Notes Hazard Class and Category Code(s) Hazard statement Code(s) Pictogram, Signal Word Code(s) Hazard statement Code(s) Suppl. Hazard statement Code(s) ‘006-035-00-8 pirimicarb (ISO); 2-(dimethylamino)-5,6-dimethylpyrimidin-4-yl dimethylcarbamate 245-430-1 23103-98-2 Carc. 2 Acute Tox. 3 Acute Tox. 3 Skin Sens. 1 Aquatic Acute 1 Aquatic Chronic 1 H351 H331 H301 H317 H400 H410 GHS08 GHS06 GHS09 Dgr H351 H331 H301 H317 H410 M = 10 M = 100’ ‘029-002-00-X dicopper oxide; copper (I) oxide 215-270-7 1317-39-1 Acute Tox. 4 Acute Tox. 4 Eye Dam. 1 Aquatic Acute 1 Aquatic Chronic 1 H332 H302 H318 H400 H410 GHS07 GHS05 GHS09 Dgr H332 H302 H318 H410 M = 100’ ‘602-020-00-0 1,2-dichloropropane; propylene dichloride 201-152-2 78-87-5 Flam. Liq. 2 Carc. 1B Acute Tox. 4* Acute Tox. 4* H225 H350 H332 H302 GHS02 GHS08 GHS07 Dgr H225 H350 H332 H302’ ‘602-033-00-1 chlorobenzene 203-628-5 108-90-7 Flam. Liq. 3 Acute Tox. 4 Skin Irrit. 2 Aquatic Chronic 2 H226 H332 H315 H411 GHS02 GHS07 GHS09 Wng H226 H332 H315 H411’ ‘603-055-00-4 propylene oxide; 1,2-epoxypropane; methyloxirane 200-879-2 75-56-9 Flam. Liq. 1 Carc. 1B Muta. 1B Acute Tox. 3 Acute Tox. 3 Acute Tox. 4 STOT SE 3 Eye Irrit. 2 H224 H350 H340 H331 H311 H302 H335 H319 GHS02 GHS08 GHS06 Dgr H224 H350 H340 H331 H311 H302 H335 H319’ ‘604-030-00-0 bisphenol A; 4,4′-isopropylidenediphenol 201-245-8 80-05-7 Repr. 1B STOT SE 3 Eye Dam. 1 Skin Sens. 1 H360F H335 H318 H317 GHS08 GHS05 GHS07 Dgr H360F H335 H318 H317’ ‘604-092-00-9 phenol, dodecyl-, branched; [1] phenol, 2-dodecyl-, branched; [2] phenol, 3-dodecyl-, branched; [3] phenol, 4-dodecyl-, branched; [4] phenol, (tetrapropenyl) derivatives [5] 310-154-3 [1] [2] [3] [4] [5] 121158-58-5 [1] [2] [3] 210555-94-5 [4] 74499-35-7 [5] Repr. 1B Skin Corr. 1C Eye Dam. 1 Aquatic Acute 1 Aquatic Chronic 1 H360F H314 H318 H400 H410 GHS08 GHS05 GHS09 Dgr H360F H314 H410 M = 10 M = 10’ ‘605-013-00-0 chloralose (INN); (R)-1,2-O-(2,2,2-trichloroethylidene)-α-D-glucofuranose; glucochloralose; anhydroglucochloral 240-016-7 15879-93-3 Acute Tox. 4* Acute Tox. 3 STOT SE 3 Aquatic Acute 1 Aquatic Chronic 1 H332 H301 H336 H400 H410 GHS06 GHS09 Dgr H332 H301 H336 H410 M = 10 M = 10 C’ ‘605-022-00-X glutaral; glutaraldehyde; 1,5-pentanedial 203-856-5 111-30-8 Acute Tox. 2 Acute Tox. 3 STOT SE 3 Skin Corr. 1B Resp. Sens. 1 Skin Sens. 1A Aquatic Acute 1 Aquatic Chronic 2 H330 H301 H335 H314 H334 H317 H400 H411 GHS06 GHS05 GHS08 GHS09 Dgr H330 H301 H335 H314 H334 H317 H410 EUH071 STOT SE 3; H335: 0,5 % ≤ C < 5 % M = 1’ ‘606-014-00-9 chlorophacinone (ISO); 2-[(4-chlorophenyl)(phenyl)acetyl]-1H-indene-1,3(2H)-dione 223-003-0 3691-35-8 Repr. 1B Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,1 % STOT RE 2; H373 (blood): 0,01 % ≤ C < 0,1 % M = 1 M = 1’ ‘606-021-00-7 N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone 212-828-1 872-50-4 Repr. 1B STOT SE 3 Skin Irrit. 2 Eye Irrit. 2 H360D*** H335 H315 H319 GHS08 GHS07 Dgr H360D*** H335 H315 H319 STOT SE 3; H335: C ≥ 10 %’ ‘607-056-00-0 warfarin (ISO); 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one; [1] (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone; [2] (R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone [3] 201-377-6 [1] 226-907-3 [2] 226-908-9 [3] 81-81-2 [1] 5543-57-7 [2] 5543-58-8 [3] Repr. 1A Acute Tox. 1 Acute Tox. 1 Acute Tox. 2 STOT RE 1 Aquatic Chronic 2 H360D H330 H310 H300 H372 (blood) H411 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H411 Repr. 1A; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,5 % STOT RE 2; H373 (blood): 0,05 % ≤ C < 0,5 %’ ‘607-059-00-7 coumatetralyl (ISO); 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin 227-424-0 5836-29-3 Repr. 1B Acute Tox. 2 Acute Tox. 3 Acute Tox. 2 STOT RE 1 Aquatic Chronic 1 H360D H330 H311 H300 H372 (blood) H410 GHS08 GHS06 GHS09 Dgr H360D H330 H311 H300 H372 (blood) H410 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 1,0 % STOT RE 2; H373 (blood) 0,1 % ≤ C < 1,0 % M = 10’ ‘607-157-00-X difenacoum (ISO); 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin 259-978-4 56073-07-5 Repr. 1B Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,02 % STOT RE 2; H373 (blood): 0,002 % ≤ C < 0,02 % M = 10 M = 10’ ‘607-172-00-1 brodifacoum (ISO); 4-hydroxy-3-(3-(4′-bromo-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)coumarin 259-980-5 56073-10-0 Repr. 1A Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 Repr. 1A; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,02 % STOT RE 2; H373 (blood): 0,002 % ≤ C < 0,02 % M = 10 M = 10’ ‘607-375-00-5 flocoumafen (ISO); reaction mass of: cis-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin and trans-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin 421-960-0 90035-08-8 Repr. 1B Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,05 % STOT RE 2; H373 (blood): 0,005 % ≤ C < 0,05 % M = 10 M = 10’ ‘607-623-00-2 diisobutyl phthalate 201-553-2 84-69-5 Repr. 1B H360Df GHS08 Dgr H360Df’ ‘613-166-00-X flumioxazin (ISO); 2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione — 103361-09-7 Repr. 1B Aquatic Acute 1 Aquatic Chronic 1 H360D H400 H410 GHS08 GHS09 Dgr H360D H410 M = 1 000 M = 1 000 ’ ‘613-121-00-4 chlorsulfuron (ISO); 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2- yl)amino]carbonyl]benzenesulphonamide 265-268-5 64902-72-3 Aquatic Acute 1 Aquatic Chronic 1 H400 H410 GHS09 Wng H410 M = 1 000 M = 100’ ‘616-011-00-4 N,N-dimethylacetamide 204-826-4 127-19-5 Repr. 1B Acute Tox. 4* Acute Tox. 4* H360D*** H332 H312 GHS08 GHS07 Dgr H360D*** H332 H312’ ‘616-037-00-6 acetochlor (ISO); 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide 251-899-3 34256-82-1 Carc. 2 Repr. 2 Acute Tox. 4 STOT SE 3 STOT RE 2 Skin Irrit. 2 Skin Sens. 1 Aquatic Acute 1 Aquatic Chronic 1 H351 H361f H332 H335 H373 (kidney) H315 H317 H400 H410 GHS08 GHS07 GHS09 Wng H351 H361f H332 H335 H373 (kidney) H315 H317 H410 M = 1 000 M = 100’ ‘616-207-00-X polyhexamethylene biguanide hydrochloride; PHMB — 32289-58-0 27083-27-8 Carc. 2 Acute Tox. 2 Acute Tox. 4 STOT RE 1 Eye Dam. 1 Skin Sens. 1B Aquatic Acute 1 Aquatic Chronic 1 H351 H330 H302 H372 (respiratory tract) (inhalation) H318 H317 H400 H410 GHS08 GHS06 GHS05 GHS09 Dgr H351 H330 H302 H372 (respiratory tract) (inhalation) H318 H317 H410 M = 10 M = 10’ (c) the following entries are inserted in accordance with the order of the index numbers: Index No International Chemical Identification EC No CAS No Classification Labelling Specific Conc. Limits, M-factors Notes Hazard Class and Category Code(s) Hazard statement Code(s) Pictogram, Signal Word Code(s) Hazard statement Code(s) Suppl. Hazard statement Code(s) ‘005-020-00-3 disodium octaborate anhydrous; [1] disodium octaborate tetrahydrate [2] 234-541-0 [1] 234-541-0 [2] 12008-41-2 [1] 12280-03-4 [2] Repr. 1B H360FD GHS08 Dgr H360FD’ ‘014-046-00-4 e-glass microfibres of representative composition; [Calcium-aluminium-silicate fibres with random orientation with the following representative composition (% given by weight): SiO 2 50,0-56,0 %, Al 2 O 3 13,0-16,0 %, B 2 O 3 5,8-10,0 %, Na 2 O < 0,6 %, K 2 O < 0,4 %, CaO 15,0-24,0 %, MgO < 5,5 %, Fe 2 O 3 < 0,5 %, F 2 < 1,0 %. Process: typically produced by flame attenuation and rotary process. (Additional individual elements may be present at low levels; the process list does not preclude innovation).] — — Carc. 1B H350i GHS08 Dgr H350i A’ ‘014-047-00-X glass microfibres of representative composition; [Calcium-aluminium-silicate fibres with random orientation with the following composition (% given by weight): SiO 2 55,0-60,0 %, Al 2 O 3 4,0-7,0 %, B 2 O 3 8,0-11,0 %, ZrO 2 0,0-4,0 %, Na 2 O 9,5-13,5 %, K 2 O 0,0-4,0 %, CaO 1,0-5,0 %, MgO 0,0-2,0 %, Fe 2 O 3 < 0,2 %, ZnO 2,0-5,0 %, BaO 3,0-6,0 %, F 2 < 1,0 %. Process: typically produced by flame attenuation and rotary process. (Additional individual elements may be present at low levels; the process list does not preclude innovation).] — — Carc. 2 H351 (inhalation) GHS08 Wng H351 (inhalation) A’ ‘029-015-00-0 copper thiocyanate 214-183-1 1111-67-7 Aquatic Acute 1 Aquatic Chronic 1 H400 H410 GHS09 Wng H410 EUH032 M = 10’ ‘029-016-00-6 copper(II) oxide 215-269-1 1317-38-0 Aquatic Acute 1 Aquatic Chronic 1 H400 H410 GHS09 Wng H410 M = 100’ ‘029-017-00-1 dicopper chloride trihydroxide 215-572-9 1332-65-6 Acute Tox. 4 Acute Tox. 3 Aquatic Acute 1 Aquatic Chronic 1 H332 H301 H400 H410 GHS06 GHS09 Dgr H332 H301 H410 M = 10’ ‘029-018-00-7 tetracopper hexahydroxide sulphate; [1] tetracopper hexahydroxide sulphate hydrate [2] 215-582-3 [1] 215-582-3 [2] 1333-22-8 [1] 12527-76-3 [2] Acute Tox. 4 Aquatic Acute 1 Aquatic Chronic 1 H302 H400 H410 GHS07 GHS09 Wng H302 H410 M = 10’ ‘029-019-01-X copper flakes (coated with aliphatic acid) — — Acute Tox. 3 Acute Tox. 4 Eye Irrit. 2 Aquatic Acute 1 Aquatic Chronic 1 H331 H302 H319 H400 H410 GHS06 GHS09 Dgr H331 H302 H319 H410 M = 10’ ‘029-020-00-8 copper(II) carbonate--copper(II) hydroxide (1:1) 235-113-6 12069-69-1 Acute Tox. 4 Acute Tox. 4 Eye Irrit. 2 Aquatic Acute 1 Aquatic Chronic 1 H332 H302 H319 H400 H410 GHS07 GHS09 Wng H332 H302 H319 H410 M = 10’ ‘029-021-00-3 copper dihydroxide; copper(II) hydroxide 243-815-9 20427-59-2 Acute Tox. 2 Acute Tox. 4 Eye Dam. 1 Aquatic Acute 1 Aquatic Chronic 1 H330 H302 H318 H400 H410 GHS06 GHS05 GHS09 Dgr H330 H302 H318 H410 M = 10’ ‘029-022-00-9 bordeaux mixture; reaction products of copper sulphate with calcium dihydroxide — 8011-63-0 Acute Tox. 4 Eye Dam. 1 Aquatic Acute 1 Aquatic Chronic 1 H332 H318 H400 H410 GHS07 GHS05 GHS09 Dgr H332 H318 H410 M = 10’ ‘029-023-00-4 copper sulphate pentahydrate 231-847-6 7758-99-8 Acute Tox. 4 Eye Dam. 1 Aquatic Acute 1 Aquatic Chronic 1 H302 H318 H400 H410 GHS07 GHS05 GHS09 Dgr H302 H318 H410 M = 10’ ‘082-013-00-1 lead powder; [particle diameter < 1 mm] 231-100-4 7439-92-1 Repr. 1A Lact. H360FD H362 GHS08 Dgr H360FD H362 Repr. 1A; H360D: C ≥ 0,03 %’ ‘082-014-00-7 lead massive: [particle diameter ≥ 1 mm] 231-100-4 7439-92-1 Repr. 1A Lact. H360FD H362 GHS08 Dgr H360FD H362’ ‘605-040-00-8 hydroxyisohexyl 3-cyclohexene carboxaldehyde (INCI); reaction mass of 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde and 3-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde; [1] 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde; [2] 3-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde [3] - [1] 250-863-4 [2] 257-187-9 [3] 130066-44-3 [1] 31906-04-4 [2] 51414-25-6 [3] Skin Sens. 1A H317 GHS07 Wng H317’ ‘607-716-00-8 bromadiolone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2 H -chromen-2-one 249-205-9 28772-56-7 Repr. 1B Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,005 % STOT RE 2; H373 (blood): 0,0005 % ≤ C < 0,005 % M = 1 M = 1’ ‘607-717-00-3 difethialone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2 H -1-benzothiopyran-2-one — 104653-34-1 Repr. 1B Acute Tox. 1 Acute Tox. 1 Acute Tox. 1 STOT RE 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H330 H310 H300 H372 (blood) H400 H410 GHS08 GHS06 GHS09 Dgr H360D H330 H310 H300 H372 (blood) H410 EUH070 Repr. 1B; H360D: C ≥ 0,003 % STOT RE 1; H372 (blood): C ≥ 0,02 % STOT RE 2; H373 (blood): 0,002 % ≤ C < 0,02 % M = 100 M = 100’ ‘607-718-00-9 perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts 206-801-3 [1] [2] [3] 375-95-1 [1] 21049-39-8 [2] 4149-60-4 [3] Carc. 2 Repr. 1B Lact. Acute Tox. 4 Acute Tox. 4 STOT RE 1 Eye Dam. 1 H351 H360Df H362 H332 H302 H372 (liver, thymus, spleen) H318 GSH08 GSH07 GHS05 Dgr H351 H360Df H362 H332 H302 H372 (liver, thymus, spleen) H318’ ‘607-719-00-4 dicyclohexyl phthalate 201-545-9 84-61-7 Repr. 1B Skin Sens. 1 H360D H317 GHS08 GHS07 Dgr H360D H317’ ‘608-067-00-3 3,7-dimethylocta-2,6-dienenitrile 225-918-0 5146-66-7 Muta. 1B H340 GHS08 Dgr H340’ ‘612-288-00-0 bupirimate (ISO); 5-butyl-2-ethylamino-6-methylpyrimidin-4-yl dimethylsulphamate 255-391-2 41483-43-6 Carc. 2 Skin Sens. 1B Aquatic Chronic 1 H351 H317 H410 GHS08 GHS07 GHS09 Wng H351 H317 H410 M = 1’ ‘612-289-00-6 triflumizole (ISO); (1 E )- N -[4-chloro-2-(trifluoromethyl)phenyl]-1-(1 H -imidazol-1-yl)-2-propoxyethanimine — 68694-11-1 Repr. 1B Acute Tox. 4 STOT RE 2 Skin Sens. 1 Aquatic Acute 1 Aquatic Chronic 1 H360D H302 H373 (liver) H317 H400 H410 GHS08 GHS07 GHS09 Dgr H360D H302 H373 (liver) H317 H410 M = 1 M = 1’ ‘616-218-00-X benzovindiflupyr (ISO); N -[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1 H -pyrazole-4-carboxamide — 1072957-71-1 Acute Tox. 3 Acute Tox. 3 Aquatic Acute 1 Aquatic Chronic 1 H331 H301 H400 H410 GHS06 GHS09 Dgr H331 H301 H410 M = 100 M = 100’ ‘616-219-00-5 fluopyram (ISO); N -{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide — 658066-35-4 Aquatic Chronic 2 H411 GHS09 H411’ ‘616-220-00-0 pencycuron (ISO); 1-[(4-chlorophenyl)methyl]-1-cyclopentyl-3-phenylurea 266-096-3 66063-05-6 Aquatic Acute 1 Aquatic Chronic 1 H400 H410 GHS09 Wng H410 M = 1 M = 1’ ‘617-023-00-2 tert -butyl hydroperoxide 200-915-7 75-91-2 Muta. 2 H341 GHS08 Wng H341’
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