List of prefixes and suffixes which, in combination with the INNs of Annex 3 to Regulation (EC) No 1549/2006, describe the salts, esters or hydrates of INNs; these salts, esters and hydrates are free of duty, on condition that they are classifiable in the same six-digit HS-subheading as the corresponding INN
ANNEX IISupplementary provisions
ANNEX II List of prefixes and suffixes which, in combination with the INNs of Annex 3 to Regulation (EC) No 1549/2006, describe the salts, esters or hydrates of INNs; these salts, esters and hydrates are free of duty, on condition that they are classifiable in the same six-digit HS-subheading as the corresponding INN Prefixes and suffixes can be combined (e.g. hydrochloride phosphate). They can be preceded by a multiplying prefix such as bi, bis, di, hemi, hepta, hexa, mono, penta, sesqui, tetra, tri, tris… (e.g. diacetate). Synonyms and systematic names can also be used, in the same way. INN means International Nonproprietary Names for pharmaceutical substances, World Health Organisation. INNRG means International Nonproprietary Names (INN) for pharmaceutical substances, Names for radicals & groups, comprehensive list 2004. INNCN means chemical or systematic name listed in International Nonproprietary Names (INN) for pharmaceutical substances, Names for radicals & groups, comprehensive list 2004. ID Preferred prefix or suffix Synonyms Systematic name when different 1 acefurate (INNRG) acetate (ester), furan-2-carboxylate (ester) (INNCN) 2 aceglumate (INNRG) rac-hydrogen N-acetylglutamate (INNCN) 3 aceponate (INNRG) acetate (ester), propanoate (ester) (INNCN) 4 acetate 5 acetonide (INNRG) propane-2,2-diylbis(oxy) (INNCN) 6 acetofenide acetophenide 1-phenylethane-1,1-diylbis(oxy) 7 1-acetoxyethyl 1-(acetyloxy)ethyl 8 aceturate (INNRG) N-acetylglycinate (INNCN) 10 acetylsalicylate 2-(acetyloxy)benzoate 11 acibutate (INNRG) acetate (ester), 2-methylpropanoate (ester) (INNCN) 12 acistrate (INNRG) acetate (ester), octadecanoate (ester) (INNCN) 13 acoxil (INNRG) (acetyloxy)methyl (INNCN) 14 adipate hexanedioate 15 alfoscerate (INNRG) (2R)-2,3-dihydroxypropyl hydrogen phosphate (INNCN) 16 alideximer (INNRG) poly([oxy(2-hydroxyethane-1,1-diyl)]{oxy[1-(hydroxymethyl)ethane-1,2-diyl]}) partly O-etherified with carboxymethyl groups with some carboxy groups amide linked to the tetrapeptide residue (glycylglycyl-L-phenylalanylglycyl) (INNCN) 17 allyl prop-2-en-1-yl 18 allylbromide allylobromide N-allyl, bromide (salt) 19 allyliodide allyloiodide N-allyl, iodide (salt) 20 aluminium 21 4-aminosalicylate aminosalicylate 2-hydroxy-4-aminobenzoate 22 ammonium 24 amsonate (INNRG) 2,2'-ethene-1,2-diylbis (5-aminobenzene-1-sulfonate) (INNCN) 25 anisatil (INNRG) 2-(4-methoxyphenyl)-2-oxoethyl (INNCN) 26 antipyrate 27 arbamel (INNRG) 2-(dimethylamino)-2-oxoethyl (INNCN) 28 argine (INNRG) 30Bα-L-arginine-30Bβ-L-arginine (INNCN) 29 arginine (INN) 30 aritox (INNRG) ricin A chain-MAB immunotoxine (INNCN) 31 ascorbate 32 aspart (INNRG) 28B-L-aspartic acid- (INNCN) 33 aspartate 34 axetil (INNRG) rac-1-(acetyloxy)ethyl (INNCN) 35 barbiturate 2,4,6(1H,3H,5H)-pyrimidinetrione 36 benetonide (INNRG) N-benzoyl-2-methyl-β-alanine (ester), acetonide (INNCN) 37 benzathine N,N'-dibenzylethylenediammonium 40 benzoacetate 41 benzoate (INNRG) 42 benzyl 43 benzylbromide benzylobromide N-benzyl, bromide (salt) 44 benzyliodide benzyloiodide N-benzyl, iodide (salt) 45 besilate (INNRG) besylate benzenesulfonate (INNCN), benzenesulphonate 47 bezomil (INNRG) (benzoyloxy)methyl (INNCN) 53 bismuth 55 borate 56 bromide (INNRG) 57 buciclate (INNRG) trans-4-butylcyclohexanecarboxylate (INNCN) 58 bunapsilate (INNRG) 3,7-di-tert-butylnaphthalene-1,5-disulfonate (INNCN) 59 buteprate (INNRG) butyrate (ester), propionate (ester) (INNCN) 60 butyl 62 tert-butyl t-butyl, tertiary butyl 67 butyl ester 69 tert-butyl ester t-butyl ester, tertiary butyl ester 75 butylbromide butylobromide N-butyl, bromide (salt) 76 butyrate butylate butanoate 77 calcium 82 camphorate 1,2,2-trimethyl-1,3-cyclopentanedicarboxylate 85 camsilate (INNRG) camsylate, camphorsulfonate, camphorsulphonate, R-camphorsulfonate, R-camphorsulphonate, S-camphorsulfonate, S-camphorsulphonate, camphor-10-sulfonate, camphor-10-sulphonate (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (INNCN) 87 caproate (INNRG) hexanoate (INNCN) 88 carbamate 89 carbesilate (INNRG) 4-sulfobenzoate (INNCN) 90 carbonate 91 chloride (INNRG) 95 choline (2-hydroxyethyl)trimethylammonium 96 ciclotate (INNRG) cyclotate 4-methylbicyclo[2.2.2]oct-2-ene-1-carboxylate (INNCN) 97 cilexetil (INNRG) rac-1-{[(cyclohexyloxy)carbonyl]oxy}ethyl (INNCN) 98 cinnamate 3-phenylprop-2-enoate 99 cipionate (INNRG) cypionate, cyclopentanepropionate 3-cyclopentylpropanoate (INNCN), 3-cyclopentylpropionate 100 citrate 2-hydroxypropane-1,2,3-tricarboxylate 101 cituxetan (INNRG) N-(4-{2(RS)-2-[bis(carboxymethyl)amino)]-3-({2-[bis(carboxymethyl)=amino]ethyl}(carboxymethyl)amino)propyl}phenyl)thiocarbamoyl (INNCN) 102 clofibrol (INNRG) 2-(4-chlorophenoxy)-2-methylpropyl (INNCN) 103 closilate (INNRG) closylate, p-chlorobenzenesulfonate, p-chlorobenzenesulphonate 4-chlorobenzene-1-sulfonate (INNCN), 4-chlorobenzenesulfonate 105 crobefate (INNRG) rac-{3-[(3E)-4-methoxybenzylidene]-2-(4-methoxyphenyl)chroman- 6-yl phosphate(2-)} (INNCN) 106 cromacate (INNRG) 2-[(6-hydroxy-4-methyl-2-oxo-2H-chromen-7yl)oxy]acetate (INNCN) 107 cromesilate (INNRG) (6,7-dihydroxy-2-oxo-2H-chromen-4-yl)methanesulfonate (INNCN) 108 crosfumaril (INNRG) (2E)-but-2-enedioyl (INNCN) 109 cyclamate (INNRG) N-cyclohexylsulfamate, N-cyclohexylsulphamate cyclohexylsulfamate (INNCN) 110a cyclohexylamine 111 cyclohexylammonium 112 cyclohexylpropionate cyclohexanepropionate cyclohexylpropanoate 118 daloxate (INNRG) L-alaninate (ester), (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (INNCN) 120 daropate (INNRG) dapropate 3-(dimethylamino)propanoate (INNCN) 121 deanil (INNRG) 2-(dimethylamino)ethyl (INNCN) 122 decanoate 123 decil (INNRG) decyl (INNCN) 124 defalan (INNRG) des-1B-L-phenylalanine-insulin (INNCN) 125 detemir (INNRG) tetradecanoyl (INNCN) 129 dibudinate (INNRG) 2,6-di-tert-butylnaphthalene-1,5-disulfonate (INNCN) 130 dibunate (INNRG) 2,6-di-tert-butylnaphthalene-1-sulfonate (INNCN) 133 dicibate (INNRG) dicyclohexylmethyl carbonate (INNCN) 134 dicyclohexylamine 135 dicyclohexylammonium 137 diethylamine 138 diethylammonium 139 diftitox (INNRG) N-L-methionyl-387-L-histidine-388-L-alanine-1-388-toxin (Corynebacterium diphtheriae strain C7) (388→2')-protein (INNCN) 142 digolil (INNRG) 2-(2-hydroxyethoxy)ethyl (INNCN) 149 dihydroxybenzoate 154 N,N-dimethyl-β-alanine N,N-dimethyl-beta-alanine 156 dinitrobenzoate 157 diolamine (INNRG) diethanolamine 2,2'-azanediyldiethanol (INNCN) 165 disulfide disulphide 169 docosil (INNRG) docosyl (INNCN) 170 dofosfate (INNRG) octadecyl hydrogen phosphate (INNCN) 171 ecamate (INNRG) N-ethylcarbamate (INNCN) 172 edamine (INNRG) ethane-1,2-diamine (INNCN) 173 edisilate (INNRG) edisylate, 1,2-ethanedisulfonate, 1,2-ethanedisulphonate ethane-1,2-disulfonate (INNCN) 175 embonate (INNRG) pamoate, 4,4'-methylenebis(3-hydroxy-2-naphthoate) 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylate) (INNCN) 176 enantate (INNRG) enanthate heptanoate (INNCN) 178 enbutate (INNRG) acetate (ester), butanoate (ester) (INNCN) 179 epolamine (INNRG) 1-pyrrolidineethanol 2-(pyrrolidin-1-yl)ethanol (INNCN) 180 erbumine (INNRG) tert-butylamine, t-butylamine, tertiary butylamine 2-methylpropan-2-amine (INNCN) 181 esilate (INNRG) esylate, ethanesulfonate, ethanesulphonate ethanesulfonate (INNCN) 182 estolate (INNRG) propionate dodecyl sulfate, propionate dodecyl sulphate, propionate lauryl sulfate, propionate lauryl sulphate propanoate (ester), dodecyl sulfate (salt) (INNCN) 184 etabonate (INNRG) ethyl carbonate (INNCN) 190 ethylbromide ethobromide N-ethyl, bromide (salt) 191 ethyl 192 ethyl ester 193 ethylamine 194 ethylammonium 195 ethylenantate ethylheptanoate 196 ethylenediamine ethane-1,2-diamine 197 ethylhexanoate 198 ethyliodide ethyloiodide N-ethyl, iodide (salt) 199 ethylsuccinate 200 etilsulfate (INNRG) ethylsulfate ethyl sulfate (INNCN) 201 farnesil (INNRG) (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl (INNCN) 202 fendizoate (INNRG) 2-(6-hydroxybiphenyl-3-carbonyl)benzoate (INNCN) 203a ferrous 204 fluoride 205 fluorosulfonate fluorosulphonate 207 formate 209 fosfatex 210 fostedate (INNRG) tetradecyl hydrogen phosphate (INNCN) 211 fumarate (2E)-but-2-enedioate 212 furetonide (INNRG) 1-benzofurane-2-carboxylate (ester), propane-2,2-diylbis(oxy) (INNCN) 213 furoate furan-2(or 3)-carboxylate 213a fusidate 214 gadolinium 215 gamolenate (INNRG) (6Z,9Z,12Z)-octadeca-6,9,12-trienoate (INNCN) 216 glargine (INNRG) 21A-glycine-30Bα-L-arginine-30Bβ-L-arginine (INNCN) 217 glucarate saccharate (2R,3S,4S,5S)-2,3,4,5-tetrahydroxyhexanedioate, D-glucarate 218 gluceptate (INNRG) glucoheptonate D-glycero-D-gulo-heptonate (INNCN) 220 gluconate 221 glucoside 222 glulisine (INNRG) 3B-L-lysine,29B-L-glutamic acid (INNCN) 223 glutamer (INNRG) glutaraldehyde polymer (INNCN) 224 glycolate hydroxyacetate 225 glyoxylate oxoacetate 226 gold 227 guacil (INNRG) 2-methoxyphenyl (INNCN) 228 guanidine 230 hemisuccinate (INNRG) hydrogen succinate hydrogen butanedioate (INNCN) 235 hexacetonide (INNRG) 3,3-dimethylbutanoate (ester), propan-2,2-diylbis(oxy) (INNCN) 238 hibenzate (INNRG) hybenzate 4-(4-hydroxybenzoyl)benzoate (INNCN) 239 hippurate N-Benzoylglycine salt 241 hyclate (INNRG) ethanol — hydrogen chloride — water (0,5 /1/0,5 ) (INNCN) 242 hydrate 243 hydrobromide 244 hydrochloride 248a hydrogen 261 hydroxide 262 hydroxybenzoate 263 2-(4-hydroxybenzoyl)benzoate o-(4-hydroxybenzoyl)benzoate 267 hydroxynaphtoate (INNRG) hydroxynaphthoate 3-hydroxynaphthalene-2-carboxylate (INNCN) 268 iodide (INNRG) 269 iodine-131 270 iron chloride 272 isetionate (INNRG) isethionate, 2-hydroxyethansulfonate, 2-hydroxyethansulphonate 2-hydroxyethane-1-sulfonate (INNCN) 273 isobutyrate 2-methylpropanoate 274 isocaproate 4-methylpentanoate 275 isonicotinate pyridine-4-carboxylate 276 isophthalate benzene-1,3-dicarboxylate 277 isopropionate 278 isopropyl propan-2-yl 279 lactate 2-hydroxypropanoate 280 lactobionate 4-O-(β-D-galactopyranosyl)-D-gluconate 281 laurate (INNRG) dodecanoate (INNCN) 282 lauril (INNRG) lauryl dodecyl (INNCN) 283 laurilsulfate (INNRG) lauril sulfate, lauril sulphate, lauryl sulfate, lauryl sulphate, laurilsulphate, laurylsulfate, laurylsulphate dodecyl sulfate (INNCN) 288 levulinate 4-oxopentanoate 289 lisetil (INNRG) L-lysinate (ester), diethyl (ester) (INNCN) 290 lisicol (INNRG) {N-[(5S)-5-carboxy-5-(3α,7α,12α-trihydroxy-5β-cholan-24-amido)pentyl]carbamothioyl}amino (INNCN) 291 lispro (INNRG) 28B-L-lysine-29B-L-proline (INNCN) 292 lithium 293 lutetium 294 lysinate lysine (INN) 296 mafenatox (INNRG) enterotoxin A (227-alanine) (Staphylococcus aureus) (INNCN) 297 magnesium 298 malate hydroxybutanedioate 299 maleate (Z)-but-2-enoate 300 malonate propanedioate 301 mandelate 2-hydroxy-2-phenylacetate, α-hydroxybenzeneacetate 302 medoxomil (INNRG) (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (INNCN) 303 megallate (INNRG) 3,4,5-trimethoxybenzoate (INNCN) 304 meglumine (INN) N-methylglucamine 1-deoxy-1-methylamino-D-glucitol 305 merpentan (INNRG) {N,N'-[1-(3-oxopropyl)ethane-1,2-diyl]bis(2-sulfanylacetamidato)}(4-) (INNCN) 306 mertansine (INNRG) tetrakis{(4RS)-4[(3-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-methyl-2-oxoethyl]methylamino}-3-oxopropyl)disulfanyl]pentanoyl} (INNCN) 307 mesilate (INNRG) mesylate, methanesulfonate, methanesulphonate methanesulfonate (INNCN) 309 metembonate (INNRG) 4,4'-methylenebis(3-methoxynaphthalene-2-carboxylate) (INNCN) 312 methonitrate (INNRG) N-methyl, nitrate (salt) (INNCN) 313 methyl ester 315 methylbromide (INNRG) methobromide N-methyl, bromide (salt) (INNCN) 317 methylenedisalicylate methylenebis(2-hydroxybenzoate) 322 metilsulfate (INNRG) metilsulphate, methylsulfate, methylsulphate methyl sulfate (INNCN) 324 metiodide (INNRG) methyliodide N-methyl, iodide (salt) (INNCN) 325 mofetil (INNRG) 2-(morpholin-4-yl)ethyl (INNCN) 330 mucate galactarate, meso-galactarate 2,3,4,5-tetrahydroxyhexane-1,6-dioate 331 nafate formate sodium formyloxy (ester), sodium (salt) 332 napadisilate (INNRG) napadisylate, 1,5-naphthalenedisulfonate, 1,5-naphthalenedisulphonate naphthalene-1,5-disulfonate (INNCN) 338 napsilate (INNRG) napsylate, 2-naphthalenesulfonate, 2-naphthalenesulphonate naphthalene-2-sulfonate (INNCN) 340 nicotinate (INNRG) pyridine-3-carboxylate (INNCN) 341 nitrate 342 nitrobenzoate 343 octil (INNRG) octyl (INNCN) 344 olamine (INNRG) ethanolamine 2-aminoethanol (INNCN) 345 oleate (INNRG) (9Z)-octadec-9-enoate (INNCN) 346 orotate 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate 348 oxalate 349 oxide 351 oxoglurate (INNRG) hydrogen 2-oxopentanedioate (INNCN) 353 palmitate (INNRG) hexadecanoate (INNCN) 356 pantothenate N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alaninate 359 pegol (INNRG) α-(2-carboxyethyl)-ω-methoxypoly(oxyethane-1,2-diyl) (INNCN) 360 pendetide (INN) 362 pentexil (INNRG) pivetil (RS)-1-[(2,2-dimethylpropanoyl)oxy]ethyl (INNCN) 363 perchlorate (INNRG) 364 phenylpropionate 365 phosphate orthophosphate 366 phosphite 367 phthalate benzene-1,2-dicarboxylate 368 picrate 2,4,6-trinitrobenzene-1-olate 369 pivalate (INNRG) trimethylacetate 2,2-dimethylpropanoate (ester) (INNCN) 371 pivoxetil (INNRG) rac-1-[(2-methoxy-2-methylpropanoyl)oxy]ethyl (INNCN) 372 pivoxil (INNRG) (pivaloyloxy)methyl [(2,2-dimethylpropanoyl)oxy]methyl (INNCN) 374 poliglumex (INNRG) [poly(L-glutamic acid)z—(L-glutamate-γ-ester)—poly(L-glutamic acid)y]n (INNCN) 375 potassium (INNRG) potassium (INNCN) 378 propionate propanoate 383 propyl 384 propyl ester 385 proxetil (INNRG) rac-1-{[(propan-2-yloxy)carbonyl]oxy}ethyl (INNCN) 386 pyridylacetate pyridinylacetate 388 quinate 1,3,4,5-tetrahydroxycyclohexanecarboxylate 389 raffimer (INNRG) (2S,4R,6R,8S,11S,13S)-2,4,8,13-tetrakis(hydroxymethyl)-4,6,11-tris(ylomethyl)-3,5,7,10,12-pentaoxatetradecane-1,14-diyl (INNCN) 390 resinate abietate (1R,4aR,4bR,10aR)-1,4a-dimethyl-7-(1-methylethyl)-1,2,3,4,4a,4b,5,6,10,10a-decahydro-1-phenanthrenecarboxylate 392 salicylate (INNRG) 2-hydroxybenzoate (INNCN) 393 salicyloylacetate 2-hydroxybenzoylacetate 394 sesquioleate (INNRG) (9Z)-octadec-9-enoate(1,5) (INNCN) 395 sodium (INNRG) 413 soproxil (INNRG) {[(propan-2-yloxy)carbonyl]oxy}methyl (INNCN) 414 steaglate (INNRG) 2-(octadecanoyloxy)acetate (ester) (INNCN) 415 stearate (INNRG) octadecanoate (INNCN) 416 stinoprate (INNRG) N-acetylcysteinate (salt), propanoate (ester) (INNCN) 417 succinate butanedioate 418 succinil (INNRG) 3-carboxypropanoyl (INNCN) 419 succinyl butanedioyl 420 sudotox (INNRG) 248-L-histidine-249-L-methionine-250-L-alanine-251-L-glutamic acid-248-613-exotoxin A (Pseudomonas aeruginosa reduced) (INNCN) 421 suleptanate (INNRG) 8-[methyl(2-sulfoethyl)amino]-8-oxooctanoate (ester), monosodium salt (INNCN) 422 sulfate (INNRG) sulphate 423 sulfinate sulphinate 424 sulfite sulphite 424a sulfobenzoate sulphobenzoate 424b 3-sulfobenzoate 3-sulphobenzoate 425 sulfosalicylate sulphosalicylate 2-hydroxysulfobenzoate 426 sulfoxylate (INNRG) sulfinomethyl, monosodium salt (INNCN) 431 tafenatox (INNRG) enterotoxin A (Staphyloccus aureus) (INNCN) 432 tannate 433 tartrate (INNRG) L-tartrate (2R,3R)-2,3-dihydroxybutanedioate (INNCN), L-tartarate 434 D-tartrate (2S,3S)-2,3-dihydroxybutanedioate, D-tartarate 435 tebutate (INNRG) tert-butylacetate, t-butyl acetate, tertiary butyl acetate 3,3-dimethylbutanoate (INNCN) 436 tenoate (INNRG) thiophene-2-carboxylate (INNCN) 437 teoclate (INNRG) theoclate, 8-chlorotheophyllinate 8-chloro-1,3-dimethyl-2,6-dioxo-3,6-dihydro-1H-purin-7-(2H)-ide (INNCN) 438 teprosilate (INNRG) 3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)propane-1-sulfonate (INNCN) 441 tetrahydrophthalate cyclohexene-1,2-dicarboxylate 444 tetraxetan (INNRG) [4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclodec-1-yl]acetyl (INNCN) 446 thiocyanate 447 tidoxil (INNRG) rac-2-(decyloxy)-3-(dodecylsulfanyl)propyl (INNCN) 448 tiuxetan (INNRG) N-(4-{(2S)-2-[bis(carboxymethyl)amino]-3-[(2RS)-{2-[bis(carboxymethyl)amino]propyl (carboxymethyl)amino]propyl} phenyl) thiocarbamoyl (INNCN) 449 tocoferil (INNRG) rac-(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl (INNCN) 450 tofesilate (INNRG) 3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)ethane-1-sulfonate (INNCN) 453 tosilate (INNRG) tosylate, p-toluenesulfonate, p-toluenesulphonate 4-methylbenzene-1-sulfonate (INNCN) 455 triclofenate (INNRG) 2,4,5-trichlorophenolate (INNCN) 458 triflutate (INNRG) trifluoroacetate (INNCN) 463 trioleate (INNRG) tris[(9Z)-octadec-9-enoate] (INNCN) 465 tristearate (INNRG) tris(octadecanoate) (INNCN) 466 trolamine (INNRG) triethanolamine 2,2',2''-nitrilotriethanol (INNCN) 467 trometamol (INN) tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol, tris(hydroxymethyl)methylamine 469 troxundate (INNRG) [2-(2-ethoxyethoxy)ethoxy]acetate (INNCN) 472 undecylate (INNRG) undecanoate (INNCN) 473 undecylenate (INNRG) undec-10-enoate (INNCN) 474 valerate (INNRG) pentanoate (INNCN) 475 xinafoate (INNRG) 1-hydroxynaphthalene-2-carboxylate (INNCN) 476 zinc