Article 1
The Annex to Regulation (EC) No 440/2008 is amended in accordance with the Annex to this Regulation.
Commission Regulation (EU) 2024/2492 of 23 September 2024 amending Regulation (EC) No 440/2008 as regards the test methods, to adapt them to technical progress
Commission Regulation (EU) 2024/2492 of 23 September 2024 amending Regulation (EC) No 440/2008 as regards the test methods, to adapt them to technical progress
Data as of 2026-07-04 · Compiled from an official source version. Later amendments or repeals may not be reflected; the official text prevails. · Read the official text ↗
Article 2
This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union .
Supplementary provisions
ANNEXSupplementary provisions
ANNEX The Annex to Regulation (EC) No 440/2008 is amended as follows: (1) Part 0 is amended as follows: (a) Table 1 is replaced by the following: ‘TABLE 1: TEST METHODS FOR PHYSICOCHEMICAL PROPERTIES OF THE SUBSTANCE Basic physicochemical properties Endpoint Test method Corresponding chapter, containing the full description of the test method, in Part A of this Annex (numbers in brackets indicate that the full description of the test method has been deleted from Part A; empty cell: no corresponding test method in Part A of this Annex) Melting point/freezing point OECD Test Guideline 102: Melting Point/Melting Range (1995) A.1. ASTM D4359-90: Standard Test Method for Determining whether a Material Is a Liquid or a Solid Test for determining fluidity according to section 2.3.4 of Annex A of the Agreement concerning the International Carriage of Dangerous Goods by Road (ADR) Boiling point OECD Test Guideline 103: Boiling point (1995) A.2. Test methods according to Table 2.6.4 of Annex I, Part 2 of Regulation (EC) No 1272/2008 Flammability EN 15188:2020 – Determination of the spontaneous ignition behaviour of dust accumulations Lower and upper explosion limit Test methods according to section 2.2.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 (ISO 10156 and EN 1839) Flash point Test methods according to table 2.6.3 of Annex I, Part 2 of Regulation (EC) No 1272/2008 Auto-ignition temperature (liquids, gases) ISO/IEC 80079-20-1:2017 – Explosive atmospheres – Part 20-1: Material characteristics for gas and vapour classification – Test methods and data Decomposition temperature Calorimetric test methods according to section 20.3.3.3 of Part II of the UN Manual of Tests and Criteria Test Series H, part II, section 28, of the UN Manual of Tests and Criteria for the self-accelerating decomposition temperature (SADT) (with reference to a specific package) pH OECD Test Guideline 122: Determination of pH, Acidity and Alkalinity (2013) Kinematic Viscosity OECD Test Guideline 114: Viscosity of Liquids (2012) Water solubility OECD Test Guideline 105: Water Solubility (1995) A.6. Partition coefficient n-octanol/water OECD Test Guideline 107: Partition Coefficient (n-octanol/water): Shake-Flask Method (1995) (A.8.) OECD Test Guideline 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method (2022) A.23. OECD Test Guideline 117: Partition Coefficient (n-octanol/water): HPLC Method (2022) A.24. Vapour pressure OECD Test Guideline 104: Vapour Pressure (2006) (A.4) Density/Relative density OECD Test Guideline 109: Density of Liquids and Solids (2012) (A.3.) DIN 66137-2 – Determination of solid state density – Part 2: Gas pycnometry ISO 12154 – Determination of density by volumetric displacement – Skeleton density by gas pycnometry Particle characteristics EU test method A.22. Length Weighted Geometric Mean Diameter of Fibres A.22. ISO 21501 – Determination of Particle Size Distribution – Single Particle Light Interaction Methods OECD Test Guideline 124: Determination of the Volume Specific Surface Area of Manufactured Nanomaterials (2022) OECD Test Guideline 125: Particle Size and Particle Size Distribution of Nanomaterials (2023) ISO/TR 14187:2020 – Surface chemical analysis –Characterization of nanostructured materials Dustiness (for nanoforms of a substance) EN 17199-1:2019 – Workplace exposure – Measurement of dustiness of bulk materials that contain or release respirable NOAA and other respirable particles EN 15051-1: Workplace exposure – Measurement of the dustiness of bulk materials – Part 1: Requirements and choice of test methods EN 15051-2: Workplace exposure – Measurement of the dustiness of bulk materials – Part 2: Rotating drum method EN 15051-3: Workplace exposure – Measurement of the dustiness of bulk materials – Part 3: Continuous drop method Surface tension OECD Test Guideline 115: Surface Tension of Aqueous Solutions (1995) A.5. Dissociation constant OECD Test Guideline 112: Dissociation Constants in Water. (1981) A.25. Hydrophobicity OECD Test Guideline 126: Determination of the Hydrophobicity Index of Manufactured Nanomaterials Through an Affinity Measurement (2023) Physicochemical hazard properties Explosives Test methods for explosives according to section 2.1.2.1. and 2.1.2.3. of Annex I, Part 2 of Regulation (EC) No 1272/2008 EU Test method A.14 Explosive Properties A.14 Flammable gases Test method for the fundamental burning velocity according to section 2.2.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Test method for pyrophoric gases according to section 2.2.4.2. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Test method for the chemical instability according to section 2.2.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Oxidising gases Test method for oxidising gases according to section 2.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Flammable liquids Test method for the sustained combustibility according to section 2.6.4.5. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Test methods for determining the flash point of flammable liquids according to section 2.6.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Flammable solids Test method for flammable solids according to section 2.7.2.3. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Self-reactive substances Test method for self-reactive substances according to section 2.8.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Pyrophoric liquids Test method for pyrophoric liquids according to section 2.9.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Pyrophoric solids Test method for pyrophoric solids according to section 2.10.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008, Self-heating substances Test method for self-heating substances according to section 2.11.2.2 of Annex I, Part 2 of Regulation (EC) No 1272/2008 Substances which in contact with water emit flammable gases Test method for substances which in contact with water emit flammable gases according to section 2.12.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Oxidising liquids Test method for oxidising liquids according to section 2.13.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Oxidising solids Test method for oxidising solids according to section 2.14.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Organic peroxides Test methods according to section 2.15.4.1 of Annex I, Part 2 of Regulation (EC) No 1272/2008 Corrosive to metals Test method for substances corrosive to metals according to section 2.16.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 Desensitised explosives Test methods according to section 2.17.2.1 (b) and (c) and according to section 2.17.2.2 of Annex I, Part 2 of Regulation (EC) No 1272/2008 Properties of polymers OECD Test Guideline 118: Determination of the Number-Average Molecular Weight and the Molecular Weight Distribution of Polymers using Gel Permeation Chromatography (1996) A.18. OECD Test Guideline 119: Determination of the Low Molecular Weight Content of a Polymer Using Gel Permeation Chromatography (1996) A.19. OECD Test Guideline 120: Solution/Extraction Behaviour of Polymers in Water (2000) (A.20.)’ (b) Table 2 is amended as follows: (i) the entry ‘Serious eye damage/eye irritation’ is replaced by the following: ‘Serious eye damage/eye irritation In vitro: OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023) (B.47.) OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023) (B.48.) OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants (2023) (B.61.) OECD Test Guideline 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023) (B.68.) OECD Test Guideline 492: Reconstructed human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2023) (B.69.) OECD Test Guideline 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification (2022) OECD Test Guideline 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2021) OECD Test Guideline 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023) OECD Test Guideline 467: Defined Approaches for Serious Eye Damage and Eye Irritation (2022) In vivo: OECD Test Guideline 405: Acute Eye Irritation/Corrosion (2023) (B.5.)’; (ii) in the entry ‘Skin sensitisation’, the ‘In vitro’ section is replaced by the following: ‘ In vitro: OECD Test Guideline 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins (2023) (B.59.) OECD Test Guideline 442D: In Vitro Skin Sensitisation Assays Addressing the AOP Key Event on Keratinocyte Activation (2022) (B.60.) OECD Test Guideline 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation (2023) (B.71.)’ OECD Test Guideline 497: Defined Approaches on Skin Sensitisation (2023); (iii) in the entry ‘Mutagenicity’, the row: ‘OECD Test Guideline 487. In vitro Mammalian Cell Micronucleus Test (2016) B.49.’ is replaced by the following: ‘OECD Test Guideline 487. In vitro Mammalian Cell Micronucleus Test (2023) (B.49.)’; (iv) in the entry ‘Endocrine disrupting properties’, the rows: ‘OECD Test Guideline 456: H295R Steroidogenesis Assay (2022) B.57.’ OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2020) are replaced by the following: ‘OECD Test Guideline 456: H295R Steroidogenesis Assay (2023) (B.57.)’ OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2023) (v) in the entry ‘Phototoxicity’, the row: ‘OECD Test Guideline 498: In Vitro Phototoxicity Test Method Using the Reconstructed Human Epidermis (RhE) (2021)’ is replaced by the following: ‘OECD Test Guideline 498: In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity test method (2023)’ (vi) the following entry is inserted after the section ‘Phototoxicity’,: ‘Immunotoxicity OECD Test Guideline 444A: In vitro immunotoxicity IL-2 Luc assay (2023)’ (c) Table 3 is amended as follows: (i) in the entry ‘Degradation’, the row: ‘OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2008)’ is replaced by the following: ‘OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2023)’ (ii) in the entry ‘Effects on sediment organisms’, the rows: ‘OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment (2004) C.27. OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Using Spiked Water (2004) C.28.’ are replaced by the following: ‘OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Test Using Spiked Sediment (2023) (C.27.) OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Test Using Spiked Water (2023) (C.28.)’; (iii) in the entry ‘Endocrine disrupting properties’, the row: ‘OECD Test Guideline 240: Medaka Extended OneGeneration Reproduction Test (MEOGRT) (2015) C.52.’ is replaced by the following: ‘OECD Test Guideline 240: Medaka Extended One Generation Reproduction Test (MEOGRT) (2023) (C.52.)’ (2) in part B, the text below the headings of each of the Chapters B.49. and B.57. is replaced by the following: ‘The full description of this test method has been deleted. The equivalent international test method appears in Part 0, Table 2.’; (3) in part C, the text below the headings of each of the Chapters C.27., C.28. and C.52. is replaced by the following: ‘The full description of this test method has been deleted. The equivalent international test method appears in Part 0, Table 3.’
Source: EUR-Lex (Publications Office of the EU), © European Union, reuse permitted under Commission Decision 2011/833/EU.
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